As we all know that Methylation is a process that transferring methyl to the other compounds from methyl compounds (e.g. S- adenosyl methionine). During this process, Various methyl compounds can be formed, or modifying certain proteins or nucleic acids chemically is to generate methylated product. In biological systems, methylation is catalyzed by the enzyme, such methylation is related to heavy metal modification , regulation of gene expression, protein function and regulation of ribonucleic acid (RNA) processing
Recently, a professor in Fudan University released a new progress in protein methylation modification research field, and the relevant achievements have been published on “molecule cell”.
Protein methylation modification is a very vital epigenetic modification, which takes part in adjusting heterochromatin formation, X chromosome inactivation, gene imprinting and repair of DNA damage. LSD1 is the first histone methylation enzyme to be identified and LSD2 is the only homolog and playing an essential role during the embryonic development.
The researcher found that LSD2 is dependent on its E3 ubiquitin ligase activity to depress tumor cell growth instead of histone methylation enzyme activity. The study found LSD2 has two separate enzyme activity. It reveals that the anti-tumor cell growth function depends on its E3 ligase activity which establishes the relation between the methylation enzyme protein and ubiquitination degradation pathway. It is a great discovery in the protein methylations field.
This is the main introduction and the development statu of protein methylation. Followings are some advantages of this technology:
Methylation is an important modification for protein and nucleic acid. It also can be used to regulate the expression of genes on and off and it has close relationship with cancer, aging, Alzheimer's and other related diseases. This is one of the important epigenetic researches. The most common methylation modification are DNA methylation and histone methylation.
Recently, a professor in Fudan University released a new progress in protein methylation modification research field, and the relevant achievements have been published on “molecule cell”.
Protein methylation modification is a very vital epigenetic modification, which takes part in adjusting heterochromatin formation, X chromosome inactivation, gene imprinting and repair of DNA damage. LSD1 is the first histone methylation enzyme to be identified and LSD2 is the only homolog and playing an essential role during the embryonic development.
The researcher found that LSD2 is dependent on its E3 ubiquitin ligase activity to depress tumor cell growth instead of histone methylation enzyme activity. The study found LSD2 has two separate enzyme activity. It reveals that the anti-tumor cell growth function depends on its E3 ligase activity which establishes the relation between the methylation enzyme protein and ubiquitination degradation pathway. It is a great discovery in the protein methylations field.
This is the main introduction and the development statu of protein methylation. Followings are some advantages of this technology:
Methylation is an important modification for protein and nucleic acid. It also can be used to regulate the expression of genes on and off and it has close relationship with cancer, aging, Alzheimer's and other related diseases. This is one of the important epigenetic researches. The most common methylation modification are DNA methylation and histone methylation.