Summary
Stable isotope labeling is a widely used tracking method for proteomics, metabolomics and its engineering. And why is it so popular? Here is the thing. Stable isotope labeling can be applied for pregnant women, newborns and other patients without radioactive contamination, and what’s more. It also has the high ability of precision and ultra-precision in quantitative and microscopic variability and flexibility.
High ability of precision and ultra-precision in quantitative
With the ability, it can detect the concentration of compound. And scientists can detect more than one sample with this technique to improve the efficiency of detection.
Microscopic variability and flexibility
This refers to the ability of marking and tracing one or more of specific atoms in the compound molecule. Variability means that to track the different metabolic pathways and the generation process with qualitative and quantitative determination.
Application
Glucose tolerance test and blood glucose control
Glucose tolerance test and blood glucose control is a simple way in the clinical field to diagnose diabetes. Examinees should drink a normal glucose and after 2-3 hours, scientists will measure the change in blood glucose concentration. With the different period of development of diabetes severity and illness, the track of blood glucose concentration is different. However, this method can only be used to detect the body's glucose metabolism, glucose metabolism of internal organs does not be provided. From this, we can see that stable isotope labeling can be used to allow doctors to personalize treatment according to the different characteristics of each patient's disease and then to achieve the purpose of improving the efficacy.
Obesity is the biggest factor that causes type II diabetes. Its pathogenesis differs from organs of the disease. Stable isotope labeling can be used to make regular checks of these groups to early detect the metabolic changes in different organs, and thus the incidence of diabetes will be early warned and prevented.
These are the main features and applicstions of stable isotope labeling.
Stable isotope labeling is a widely used tracking method for proteomics, metabolomics and its engineering. And why is it so popular? Here is the thing. Stable isotope labeling can be applied for pregnant women, newborns and other patients without radioactive contamination, and what’s more. It also has the high ability of precision and ultra-precision in quantitative and microscopic variability and flexibility.
High ability of precision and ultra-precision in quantitative
With the ability, it can detect the concentration of compound. And scientists can detect more than one sample with this technique to improve the efficiency of detection.
Microscopic variability and flexibility
This refers to the ability of marking and tracing one or more of specific atoms in the compound molecule. Variability means that to track the different metabolic pathways and the generation process with qualitative and quantitative determination.
Application
Glucose tolerance test and blood glucose control
Glucose tolerance test and blood glucose control is a simple way in the clinical field to diagnose diabetes. Examinees should drink a normal glucose and after 2-3 hours, scientists will measure the change in blood glucose concentration. With the different period of development of diabetes severity and illness, the track of blood glucose concentration is different. However, this method can only be used to detect the body's glucose metabolism, glucose metabolism of internal organs does not be provided. From this, we can see that stable isotope labeling can be used to allow doctors to personalize treatment according to the different characteristics of each patient's disease and then to achieve the purpose of improving the efficacy.
Obesity is the biggest factor that causes type II diabetes. Its pathogenesis differs from organs of the disease. Stable isotope labeling can be used to make regular checks of these groups to early detect the metabolic changes in different organs, and thus the incidence of diabetes will be early warned and prevented.
These are the main features and applicstions of stable isotope labeling.